Mouse anti Human B7.1 (extra-cellular domain)Catalogue number: 0861
|Product Type||Monoclonal Antibody|
Cell Distribution: CD86 antibody is rapidly induced on the surface of and is expressed at high levels on dendritic cells. It is also found on malignant Hodgkin and Reed-Sternberg (H-RS) cells in HodgkinÕs disease.Function: CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient costimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD80 in T helper cell differentiation.
Synonyms: CD86, mouse Anti Human B7.2 unconjugated
Immunogen: Recombinant expressed extra-cellular domain of human CD86.
Product Form: Unconjugated
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
Purification Method: Protein A/G Chromatography
Purity: > 95 % by SDS PAGE
Concentration: See vial for concentration
Antibody can be used for flow cytometry and immunohistochemistry. Optimal concentration should be evaluated by serial dilutions.
Functional Analysis: Western Blotting, Flow cytometry, Immunohistochemistry.
Positive Control: Specificity: Recognizes the extra-cellular domain of human CD86 (also called B7-2). Does not bind the extracellular domain of CD80.
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: Products are stable for one year from purchase when stored properly
Ship Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
1. Chan, E.P.H., et al. 'Effects of titanium(IV) ions on human monocyte-derived dendritic cells.' Metallomics 2009, 1, 166-174.
Database Name: UniProt
Accession number: P42081
Safety Datasheet(s) for this product:
Mouse anti Human B7.1 (extra-cellular domain)