Exalpha Biologicals, Inc.

Product Highlight

FIX&PERM Cell Fixation and Permeabilization Kit

Flow cytometric analyses with monoclonal antibodies were so far mainly restricted to cell surface molecules. Intracellular structures such as cytoplasmic or nuclear enzymes, oncoproteins, cytokines, immunoglobulins etc. were largely excluded from such studies. Also excluded from flow cytometric studies were cytoplasmic localizations of well-established membrane molecules like CD3 and CD22, which, in their cytoplasmic form, are the most reliable lineage markers in undifferentiated leukemia. With the FIX&PERM® Kit flow cytometric analysis of intracellular antigens has become as easy as surface antigen studies. The only prerequisite is the availability of suitable antibody conjugates. Most of the available monoclonal antibody conjugates can be used with the FIX&PERM® Kit, some determinants are sensitive, however, to the fixation step involved. This and the optimal fixation time have to be tested for each reagent.

News

Welcome, Peter Rutten

We are pleased to announce that Peter Rutten has now started in his role as Operations Director here at Exalpha Biologicals Inc. Peter has a Master’s of Science degree in Industrial and Organizational Psychology and this has lead him down a very business orientated career path. Peter is looking forward to working with the team at Exalpha. Peters primary focus is the customer experience and he will be working with the Laboratory team, the Quality Control team and the Order Processing team to ensure this focus is achieved. We all wish Peter well in his new role.

Resources

EXALPHA USEFUL LINKS

National Center for Biotechnology information (NCBI)
The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information.
http://www.ncbi.nlm.nih.gov/
 
Roadmap Epigenomics Project
The NIH Roadmap Epigenomics Mapping Consortium was launched with the goal of producing a public resource of human epigenomic data to catalyze basic biology and disease-oriented research.
http://www.roadmapepigenomics.org
 
ExPASy Proteomics Server
The ExPASy (Expert Protein Analysis System) proteomics server of the Swiss Institute of Bioinformatics (SIB) is dedicated to the analysis of protein sequences and structures.
http://www.expasy.ch/
 
Human Protein Reference Database
The Human Protein Reference Database represents a centralized platform to visually depict and integrate information pertaining to domain architecture, post-translational modifications, interaction networks and disease association for each protein in the human proteome.
http://www.hprd.org/
 
GeneCards
GeneCards® is a searchable, integrated database of human genes that provides concise genomic, proteomic, transcriptomic, genetic and functional information on all known and predicted human genes.
http://www.genecards.org/index.shtml
 
NCI, SEER (Surveillance Epidemiology and End Results)
Providing information on cancer statistics.
http://seer.cancer.gov/
 
PUCL
Purdue University Cytometry Labs. Cytomics information and educational material.
http://www.cyto.purdue.edu/
 
World Intellectual Property Organization (WIPO)
The Intellectual Property Digital Library Web site provides access to intellectual property data collections hosted by the World Intellectual Property Organization.
http://www.wipo.int/ipdl/en/
 
BioModels Database - A database of Annotated Published Models
BioModels Database is a data resource that allows biologists to store, search and retrieve published mathematical models of biological interests. Models present in BioModels Database are annotated and linked to relevant data resources, such as publications, databases of compounds and pathways, controlled vocabularies, etc.
http://www.ebi.ac.uk/biomodels-main/
 
The Molecular Level
Tools for Structural Biology Education and Training   Tools for Structural Biology Education and Training
http://spdbv.vital-it.ch/TheMolecularLevel/index.html
 
BioCyc
BioCyc is a collection of 505 Pathway/Genome Databases. Each database in the BioCyc collection describes the genome and metabolic pathways of a single organism.
http://www.biocyc.org/
 
Genatlas
GENATLAS contains relevant information with respect to gene mapping and genetic diseases.
http://genatlas.medecine.univ-paris5.fr/
 
Harvester
Harvester crawls and crosslinks numerous sites.
http://harvester.fzk.de/harvester/
 
Mapping Epitopes on Protein Surfaces
Given a protein PDB file, MEPS generate all peptides of a given length (with mismatches) able to mimic exposed regions of the protein.
http://bcc20.caspur.it/meps/index.php
 
Stanford University Library
Stanford University Library - HighWire Press hosts the largest repository of free, full-text, peer-reviewed content, with 915 journals and 1,149,154 free, full-text articles online.
http://highwire.stanford.edu/lists/allsites.dtl
 
The Sequence Manipulation Suite
The Sequence Manipulation Suite is a collection of web-based programs for analyzing and formatting DNA and protein sequences.
http://bioinformatics.org/sms/index.html
 
Protocol Online
Protocol Online is a database of research protocols in a variety of life science fields.
http://www.protocol-online.org/
 
Primer3
Primer3 is a widely used program for designing PCR primers.
http://frodo.wi.mit.edu/primer3/
 
siRNA
siRNA - This site helps you select siRNAs to knock down your gene of interest.
http://sirna.wi.mit.edu/
 
Venn Diagram Generator (2 way)
Venn Diagram Generator (2 way)
http://jura.wi.mit.edu/bioc/tools/venn.php
 
Venn Diagram Generator (3 way)
Venn Diagram Generator (3 way)
http://http://jura.wi.mit.edu/bioc/tools/venn3way/index.php
 
Redundant List Analysis
Redundant List Analysis
http://jura.wi.mit.edu/bioc/tools/redundant/
 
Compare Two Lists
Compare Two Lists
http://jura.wi.mit.edu/bioc/tools/compare.php
 
Compare Three Lists
Compare Three Lists
http://jura.wi.mit.edu/bioc/tools/compare_3_lists.php
 
Extract UTR Calculator
Extract UTR Calculator
http://jura.wi.mit.edu/bioc/tools/utrs/