Rabbit anti Mouse Survivin (CT) (TIAP) (Inhibitor of Apoptosis)Catalog number: X1132P
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP1-3. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas1,3.
Synonyms: Anti-Mouse Survivin (C-terminal); Anti-Mouse TIAP (C-terminal); Anti-Mouse API4 (C-terminal)
Immunogen: Synthetic peptide corresponding to amino acids 128 to 140 of mouse survivin protein.
Product Form: Unconjugated
Formulation: Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative
Purification Method: Antigen Immunoaffiinity Purification
Concentration: See vial for concentration
Detects survivin protein by Western blot at 0.5 to 1 µg/ml. Detects 17 kDa band in mouse spleen tissue lysate. Optimal concentration should be evaluated by serial dilutions.
Functional Analysis: Western Blotting
Positive Control: Mouse spleen tissue lysate
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: See expiration date on vial
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.
1. Ambrosini, G., et al. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 1997, 3, 917-921 2. Li, F., et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998, 396, 580-584 3. Kobayashi, K., et al. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc. Natl. Acad. Sci. USA 1999, 96, 1457-1462
Database Name: SwissProt
Accession Number: O70201
Species Accession: Mouse
Safety Datasheet(s) for this product:
Rabbit anti Mouse Survivin (CT) (TIAP) (Inhibitor of Apoptosis)
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" Western blot analys using anti-mSurvivin (CT) antibody at 1 µg/ml on mouse spleen tissue lysate."