Rabbit anti Human Sphingosine Kinase 2, Long FormCatalog number: X1880P
Antigen Immunoaffinity Purified Polyclonal
Rat sphingosine kinase 1 catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (spp)(sphingosine + ATP = sphingosine 1-phosphate + ADP), a lipid mediator with both intra- and extracellular functions. also acts on d-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as d,l-threo-dihydrosphingosine, n,n-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. The long form of sphingosine kinase 1, an N-terminal extension, is responsible for FceRI-mediated calcium mobilization and may play a role in other ligand mediated signaling events.
Synonyms: Sphk2-L, N-terminal-extended Sphingosine Kinase 2
Immunogen: Synthetic peptide derived from the N-terminal extension of the Sphingosine Kinase 2-L protein.
Product Form: Affinity Purified
Formulation: Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08% sodium azide
Purification Method: Antigen Immunoaffiinity Purification
Concentration: Lot specific, see vial
Antibody can be used for Western blotting (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Functional Analysis: Western Blotting
Positive Control: Jurkat lysate used as positive control.
Product should be stored at -70ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: See expiration date on vial
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.
1. Okada, T., et al. 'Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis.' J. Biol. Chem. 2005, 280, 36318-36325
Database Name: UniProt
Accession Number: Q9NRA0
Species Accession: Human
Safety Datasheet(s) for this product:
Rabbit anti Human Sphingosine Kinase 2, Long Form
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|Western blot of endogneous sphingosine kinase 2 LF detection in Jurkat cell lysate (4 ug/lane) using X1880P (1 ug/ml) developed using anti-rabbit HRp (1:75K) and Pierce Super Signal west Femto.|
Western blot of endogneous sphingosine kinase 2 LF detection in Jurkat cell lysate (4 ug/lane) using X1880P (1 ug/ml) developed using anti-rabbit HRp (1:75K) and Pierce Super Signal west Femto.