Rabbit anti Human Lass2Catalog number: X2307P
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Antigen Immunoaffinity Purified Polyclonal
LASS2, a human homologue of the yeast longevity assurance gene LAG1 is highly expressed in liver and kidney as compared to the expression of the human LAG1 homologue LAG1Hs-1. LASS2 is located on chromosome 1q11. The LASS2 protein interacts with several membrane-associated receptors or transporters. LASS2 protein inhibits the colony formation of human hepatoma cells in vitro, which suggests that this gene may be involved in the regulation of cell growth.
Synonyms: LAG1 longevity assurance homolog 2, Tumor metastasis-suppressor gene 1 protein, SP260
Immunogen: Synthetic peptide derived from human Lass2 protein
Product Form: Affinity Purified
Formulation: Provided as a solution in Tris buffered saline with 0.08% sodium azide, 10mM MgCl2, 10mM ammonium sulfate, and 0.2% lactose.
Purification Method: Antigen Immunoaffiinity Purification
Concentration: Lot specific, see vial
Antibody can be used for Western blotting (1:400 starting dilution) and immunohistochemistry (10-15 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Functional Analysis: Western Blotting
Positive Control: liver and kidney
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: See expiration date on vial
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.
1: Becker I, Wang-Eckhardt L, Yaghootfam A, Gieselmann V, Eckhardt M.Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2. Histochem Cell Biol. 2008 Feb;129(2):233-41. Epub 2007 Sep 28. 2: Wang X, Carré W, Saxton AM, Cogburn LA. Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken. Cytogenet Genome Res. 2007;117(1-4):174-88. 3:Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B. Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol Cancer Ther. 2007 Feb;6(2):712-22. 4: Yu Y, Lu H, Pan H, Ma JH, Ding ZJ, Li YY. Expression of LASS2 controlled by LAG1 or ADH1 promoters cannot functionally complement Lag1p. Microbiol Res. 2006;161(3):203-11. Epub 2005 Sep 22.
Database Name: UniProt
Accession Number: Q96G23
Species Accession: Human
Safety Datasheet(s) for this product:
Western blot analysis using LAG1 longevity assurance homolog 2 (Cat. # X2307P) at 10ug/ml on human placenta lysate (Cat. # X1635C) 14 ug/lane. Lane A] antibody alone, Lane B] conjugate alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:10K dilution (Cat. # X1207M). Exposure for 5 minutes