Mouse anti Human Rb (Retinoblastoma)Catalog number: N130M
Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.
Synonyms: Retinoblastoma-associated protein; pRb; pp110; p105-Rb
Mice were immunized with a recombinant protein corresponding to amino acids 300 to 380 of the human retinoblastoma sequence
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Product Form: Unconjugated
Purification Method: Protein A/G Chromatography
Concentration: See vial for concentration
Functional Analysis: Immunoprecipitation
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: See expiration date on vial
Shipping Conditions: Ship at ambient temperature.
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.
1) E.Harlow et. al. (1991) Mol. Cell Biol., 11: 5792-5799
Database Name: UniProt
Accession Number: P06400 (Human)
Species Accession: Human
Safety Datasheet(s) for this product:
Mouse anti Human Rb (Retinoblastoma)
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