Human c-myc belongs to a family of 5 myc oncogenes. Amplification of c-myc has been found in several tpes of human tumors including breast and colon carcinomas. Induction of c-myc in cells grown in the appropriate growth factors or co-expression with survival genes, such as bcl-2 causes cell proliferation. In the abscence of these factors, c-myc expression causes cell death. c-myc gene gives rise to at least two nuclear phosphoproteins of 64kDa and 67kDa.
Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant full-length human c-Myc protein and mouse myeloma cells.
Provided as solution in phosphate buffered saline with 0.08% sodium azide
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