Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

EDG4 (LPA2), C terminal (DISCONTINUED)

  • Product Code: c181m
  • Size: 100 µg
  • Price (USD): $425

Cat #

c181m		 Quantity:      

Product Name

EDG4 (LPA2), C terminal (DISCONTINUED)

Synonyms

EDG-4 ct, mouse anti human endothelial cell differentiation gene 4, c terminal

Host/Source

Mouse

Clone

AS63

Isotype

IgG

Product Type

Monoclonal Antibody

Reactivity

Human

Applications

Western Blot

Size

100 µg

Price (USD)

$425

Background

EDG-4 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-4 is lysophospholipid. There are 6 known members of the EDG receptor family and they are implicated in mediating growthrelated effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG4 is expressed in testes, ovarian tumor and leukocyte containing tissues.

Formulation

Provided as a 0.2 ?m sterile-filtered solution in Ca++ & Mg++ free Dulbecco's PBS and 0.05% sodium azide.

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

39.0

Database Links:

SwissProtQ9HBW0Human

References

1.Diversity of cellular receptors and functions for the lysophospholipid growth factos lysophosphatidic acid and sphingosine 1-phosphate. Goetzl EJ and An, S. FASEB J 1998 Dec;12(15):1589-98. 2. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. An S; Goetzl EJ; Lee H. J Cell Biochem Suppl 1998;30-31:147-57.