Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine 1 Phosphate 3 Receptor (EDG-3) CT

  • Product Code: c176m
  • Size: 100 µg
  • Price (USD): $438

Cat #

c176m		 Quantity:      

Product Name

Sphingosine 1 Phosphate 3 Receptor (EDG-3) CT

Synonyms

Endothelial Cell Differentiation Gene-3 C-terminal

Host/Source

Mouse

Clone

AS61

Isotype

IgG

Product Type

Monoclonal Antibody

Reactivity

Human, Rat

Applications

Western Blot

Purification

Protein A/G Chromatography

Size

100 µg

Price (USD)

$438

Background

Endothelin cell differentation gene-3 (EDG-3) belongs to a family of G-protein couple receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family. They have been implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing and other tissues.

Immunogen

Human Endothelial Differentiation Gene-3 unique C-terminal peptide

Positive Control

Specificity: Recognizes human EDG-3. Does not recognize EDG-5.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

42.3

Database Links:

SwissProtQ99500Human

References

1. Goetzl EJ and An, S. Diversity of cellular receptors and functions for the lysophospholipid growth factos lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 1998, 12, 1589-98. 2. An, S., Goetzl, E.J., Lee, H. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. Cell Biochem. Suppl. 1998, 30-31, 147-57.


Product Specific References


This product has been used in:

1. Ishii, Isao, et al., 'Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phentoypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPb3/EDG3' The Journal of Biogical Chemistry 2001, 276, 36, 33697-33704 2. Coussin, Frederic, et al, 'Comparison of Sphingosine 1-Phosphate-Induced Intracellular Signaling Pathways in Vascular Smooth Muscles' Circulation Research 2002, 91, , 151-157 3. Sun, X., et al. 'Sphingosine-1-Phosphate Receptor-3 Is a Novel Biomarker in Acute Lung Injury.' American Journal of Respiratory Cell and Molecular Biology, Nov 2012, 47(5): 628-636.