Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine 1 Phosphate 3 Receptor (EDG-3) CT

  • Product Code: c176m
  • Size: 100 µg
  • Price (USD): $438

Cat #

c176m		 Quantity:      

Product Name

Sphingosine 1 Phosphate 3 Receptor (EDG-3) CT


Endothelial Cell Differentiation Gene-3 C-terminal







Product Type

Monoclonal Antibody


Human, Rat


Western Blot


Protein A/G Chromatography


100 µg

Price (USD)



Endothelin cell differentation gene-3 (EDG-3) belongs to a family of G-protein couple receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family. They have been implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing and other tissues.


Human Endothelial Differentiation Gene-3 unique C-terminal peptide

Positive Control

Specificity: Recognizes human EDG-3. Does not recognize EDG-5.


Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight


Database Links:



1. Goetzl EJ and An, S. Diversity of cellular receptors and functions for the lysophospholipid growth factos lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 1998, 12, 1589-98. 2. An, S., Goetzl, E.J., Lee, H. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. Cell Biochem. Suppl. 1998, 30-31, 147-57.

Product Specific References

This product has been used in:

1. Ishii, Isao, et al., 'Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phentoypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPb3/EDG3' The Journal of Biogical Chemistry 2001, 276, 36, 33697-33704 2. Coussin, Frederic, et al, 'Comparison of Sphingosine 1-Phosphate-Induced Intracellular Signaling Pathways in Vascular Smooth Muscles' Circulation Research 2002, 91, , 151-157 3. Sun, X., et al. 'Sphingosine-1-Phosphate Receptor-3 Is a Novel Biomarker in Acute Lung Injury.' American Journal of Respiratory Cell and Molecular Biology, Nov 2012, 47(5): 628-636.