Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc.

a1G Calcium Channel

  • Product Code: X2715P
  • Size: 100 µg
  • Availability: In Stock In Stock
  • Price (USD): $355

Cat #

X2715P		 Quantity:      

Data Sheet

Product Name

a1G Calcium Channel

Synonyms

Voltage-Dependent T-Type Calcium Channel, alpha1G subunit; Cncna1G

Host/Source

Rabbit

Isotype

IgG

Product Type

Antigen Immunoaffinity Purified Polyclonal

Reactivity

Human

Applications

Western Blot

Purification

Antigen Immunoaffiinity Purification

Size

100 µg

Price (USD)

$355

Background

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1g gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. alpha(1G) is most likely responsible for burst firing in thalamic relay cells. These neurons burst during various thalamocortical oscillations including absence seizures the modulation of the intrinsic firing pattern mediated by alpha(1G) T-type Ca(2+) channels plays a critical role in the genesis of absence seizures in the thalamocortical pathway.

Immunogen

Synthetic peptide derived from the rat alpha1G calcium channel conjugated to KLH

Positive Control

Rat brain lysate, human melanoma tissue

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

248

Product Image

Image Legend

Immunohistochemical staining of human melanoma tumor tissue using alpha1G calcium channel antibody (Cat. No. X2715P) at 15 µg/ml.

Database Links:

SwissProtO43497Human

References

1. Perez-Reyes, E et.al. 'Molecular characterization of a neuronal low-voltage-activatedT-type calcium channel' Nature 391 (6670), 896-900 (1998)

2.Sohal,VS. et al. 'It takes T to tango.' Neuron 31(1):3-4 (2001)

3. Kim, D. et.al. 'Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels.' Neuron 31(1):35-45 (2001)