Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Acid Acid Ceramidase 1

  • Product Code: X2407P
  • Size: 100 µg
  • Price (USD): $210

Cat #

X2407P		 Quantity:      

Product Name

Acid Acid Ceramidase 1

Synonyms

N-acylsphingosine amidohydrolase (Acid ceramidase) 1; ASAH1

Host/Source

Rabbit

Isotype

IgG

Product Type

Polyclonal Antibody

Reactivity

Human

Applications

Western Blotting, ELISA

Purification

Ammonium Sulfate Precipitation

Size

100 µg

Price (USD)

$210

Background

Acid ceramidase is a lipid hydrolyase responsible for the degradation of ceramide into sphingosine and free fatty acids within lysosomes. It can also synthesize ceramide from sphingosine and free fatty acids as well. The reverse activity is pH dependent (6.0 vs 4.5, respectively). This suggests that the enzyme may have diverse functions within cells dependent on its subcellular location and the local pH. Recent studies have shown that acid ceramidase activity is aberrantly expressed in several human cancers and that it might be a useful drug target. As an example, inhibitors of enzyme activity have been shown to slow the growth of cancer cells alone or in combination with other established, anti-oncogenic treatments. Aberrant activity has also been shown in Alzheimer's disease and overexpression may prevent insulin resistant (Type II) diabetes by free fatty acids.

Immunogen

Synthetic peptide derived from the C terminal region of the ASAH1 protein.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

44 kDa

Database Links:

SwissProtQ9WV54Mouse
SwissProtQ9EQJ6Rat
SwissProtQ53H01Human

References

1. Park, J.H., et al. 'Acid ceramidase and human disease.' Biochim Biophys Acta 2006; 1758:2133-2138. 2. Zeidan, Y.H., et al. 'Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.' J. Biol. Chem. 2006; 281:24695-24703. 3. Shtraizent, N., et al. 'Autoproteolytic cleavage and activation of human acid ceramidase.' J. Biol. Chem. 2008; 283:11253-11259.