Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc.

a1A Calcium Channel

  • Product Code: X2391P
  • Size: 100 µg
  • Price (USD): $304

Cat #

X2391P		 Quantity:      

Data Sheet

Product Name

a1A Calcium Channel

Synonyms

CaV2.1; P/Q-type Voltage-Gated Ca2+ Channel; Cacna1

Host/Source

Rabbit

Isotype

IgG

Product Type

Antigen Immunoaffinity Purified Polyclonal

Reactivity

Human, Rat

Applications

Western Blot, Immunohistochemistry

Purification

Antigen Immunoaffiinity Purification

Size

100 µg

Price (USD)

$304

Background

Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1a gives rise to p and/or q-type calcium currents. P/q-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by the funnel toxin (ftx) and by the omega-agatoxin-IVA (omega-aga-IVA). They are however insensitive to dihydropyridines (dhp), and omega- conotoxin-GVIA (omega-ctx-GVIA). voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Immunogen

Synthetic peptide derived from the rat α1A calcium channel conjugated to KLH

Positive Control

Rat brain lysate, human brain tissue

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

251 kDa

Product Image

Image Legend

Immunohistochemical staining of normal human brain tissue using alpha1A calcium channel antibody (Cat. No. X2391P) at 15 µg/ml

Database Links:

SwissProtO00555Human
SwissProtP54282Rat

References

1. Starr,T.V.B et.al 'Primary structure of a calcium channel that is highly expressed in the rat cerebellum' Proc. Natl. Acad. Sci. U.S.A. 88, 5621-5625 (1991)

2. Snutch,T.Pet.al 'Rat brain expresses a heterogeneous family of calcium channels' Proc. Natl. Acad. Sci. U.S.A. 87 (9), 3391-3395 (1990)

3. Yu,A.S et.al. 'Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney' Proc. Natl. Acad. Sci. U.S.A. 89 (21), 10494-10498 (1992)

4. Hansen PB, , et al.'Vascular smooth muscle cells express the alpha(1A) subunit of a P-/Q-type voltage-dependent Ca(2+)Channel, and It is functionally important in renal afferent arterioles.' Circ Res (United States) 87(10) p896-902 (2000)

5. Stephens,G.I. et.al 'The Cav2.1/alpha1A (P/Q-type) voltage-dependent calcium channel mediates inhibitory neurotransmission onto mouse cerebellar Purkinje cells.' Eur J Neurosci 13(10) 1902-12 (2001)