Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.
AHR staining of formalin fixed paraffin embedded respiratory epithelium and bronchial smooth muscle tissue at a dilution of 6 µg/ml. Antigen retrieval using a citrate buffer and steam/heat was utilized.