Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

ATP-Binding Cassette, Sub-Family B (Mdr/Tap), Member 1 (Abcb1)

  • Product Code: X2192P
  • Size: 50 µg
  • Price (USD): $464

Cat #

X2192P		 Quantity:      

Data Sheet

Product Name

ATP-Binding Cassette, Sub-Family B (Mdr/Tap), Member 1 (Abcb1)

Synonyms

ABC20, ABCB1, CD243, CLCS, EC 3.6.3.44, GP170, MDR1, P-GP, PGY1

Host/Source

Rabbit

Isotype

IgG

Product Type

Antigen Immunoaffinity Purified Polyclonal

Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Purification

Immunoaffinity Purification

Size

50 µg

Price (USD)

$464

Background

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13). Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases.

Immunogen

Cytoplasmic domain of human

Positive Control

Human adrenal cortex tissue

Formulation

Phosphate buffered saline containing 0.1% sodium azide

Customer Storage

Product should be stored at -70ºC. Aliquot to avoid freeze/thaw cycles

Product Image

Image Legend

Abcb1 staining of formalin fixed paraffin embedded adrenal cortex tissue at a dilution of 20 µg/ml. Antigen retrieval using a citrate buffer and steam/heat was utilized.

Database Links:

SwissProtP08183Human

References

1. Brant, S.R., et al. 'MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.' Am. J. Hum. Genet. 2003, 73, 1282-1292