Exalpha Biologicals, Inc.

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Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and our focus is on developing antibodies targetting Cell Adhesion, Nuclear and Cytoskeletal Proteins.

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Exalpha Biologicals, Inc.

CCR10 (G-protein-Coupled Receptor GPR2)

  • Product Code: X2094P
  • Size: 50 µg
  • Availability: In Stock In Stock
  • Price (USD): $464

Cat #

X2094P		 Quantity:      

Data Sheet

Product Name

CCR10 (G-protein-Coupled Receptor GPR2)

Synonyms

CC-CKR-10, CCBP2, CCR-10, CCR10, CCR9, CMKBR9, D6, GPR2

Host/Source

Rabbit

Isotype

IgG

Product Type

Antigen Immunoaffinity Purified Polyclonal

Reactivity

Human

Applications

Immunohistochemistry

Purification

Immunoaffinity Purification

Size

50 µg

Price (USD)

$464

Background

CCR10 belongs to the G-protein coupled receptor 1 family. It is the receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Immunogen

A synthetic peptide to the N-terminal domain of human CCR10, linked to KLH

Positive Control

Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.

Formulation

Phosphate buffered saline containing 0.1% sodium azide

Customer Storage

Product should be stored at -70°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

38.4 kDa

Product Image

Image Legend

CCR10 staining of formallin fixed paraffin embedded human skin tissue at a dilution of 5ug/ml. Antigen retrieval using a citrate buffer and steam/heat was utilized.

Database Links:

SwissProtP46092Human

References

1. Bonini, J.A., et al 'Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3.' DNA Cell Biol 1997, 16, 1249-1256

2. Xiong, N., et al. 'CCR10 and its ligands in regulation of epithelial immunity and diseases.' Protein Cell 2012, epub

3. Mirshahpanah, P., et al. 'CCR4 and CCR10 ligands play additive roles in mouse contact hypersensitivity.' Exp. Dermatol. 2008, 17, 30-34