Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine Kinase 2, Long Form, Human

  • Product Code: X1880P
  • Size: 100 µg
  • Price (USD): $355

Cat #

X1880P		 Quantity:      

Data Sheet

Product Name

Sphingosine Kinase 2, Long Form, Human

Synonyms

Sphk2-L, N-terminal-extended Sphingosine Kinase 2

Host/Source

Rabbit

Isotype

IgG

Product Type

Antigen Immunoaffinity Purified Polyclonal

Reactivity

Human

Applications

Western Blot, ELISA

Purification

Antigen Immunoaffiinity Purification

Size

100 µg

Price (USD)

$355

Background

Rat sphingosine kinase 1 catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (spp)(sphingosine + ATP = sphingosine 1-phosphate + ADP), a lipid mediator with both intra- and extracellular functions. also acts on d-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as d,l-threo-dihydrosphingosine, n,n-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. The long form of sphingosine kinase 1, an N-terminal extension, is responsible for FceRI-mediated calcium mobilization and may play a role in other ligand mediated signaling events.

Immunogen

Synthetic peptide derived from the N-terminal extension of the Sphingosine Kinase 2-L protein.

Positive Control

Jurkat lysate used as positive control.

Formulation

Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -70°C. Aliquot to avoid freeze/thaw cycles

Product Image

Image Legend

Western blot of endogneous sphingosine kinase 2 LF detection in Jurkat cell lysate (4 ug/lane) using X1880P (1 ug/ml) developed using anti-rabbit HRp (1:75K) and Pierce Super Signal west Femto.

Database Links:

SwissProtQ9NRA0Human

References

1. Okada, T., et al. 'Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis.' J. Biol. Chem. 2005, 280, 36318-36325