Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine 1 Phosphate 3 Receptor (EDG-3) CT

  • Product Code: X1690B
  • Size: 50 µg
  • Price (USD): $113

Cat #

X1690B		 Quantity:      

Data Sheet

Product Name

Sphingosine 1 Phosphate 3 Receptor (EDG-3) CT

Product Type

Blocking Peptide

Applications

Antibody function blocking

Size

50 µg

Price (USD)

$113

Background

Endothelial cell differentation gene-3 (EDG3) belongs to a family of G-protein couple receptors whose ligands are lysophospholipids. The ligand for EDG3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family. They have been implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG3 is expressed in cardiovascular, leukocyte-containing and other tissues.

Formulation

Provided in solution at 1 mg/ml in phosphate buffered saline.

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Database Links:

SwissProtQ99500Human