Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Lysophosphatidic Acid Receptor 2 (EDG4) CT

  • Product Code: X1573B
  • Size: 50 µg
  • Price (USD): $113

Cat #

X1573B		 Quantity:      

Data Sheet

Product Name

Lysophosphatidic Acid Receptor 2 (EDG4) CT

Product Type

Blocking Peptide

Reactivity

Human

Applications

Antibody function blocking

Size

50 µg

Price (USD)

$113

Background

EDG4 (LPA2) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG4 (LPA2) is lysophospholipid. There are 6 known members of the EDG receptor family and they are implicated in mediating growthrelated effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG4 (LPA2) is expressed in testes, ovarian tumor and leukocyte containing tissues.

Formulation

Provided in solution at 1 mg/ml in phosphate buffered saline.

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

References

1. Goetzl EJ and An, S. Diversity of cellular receptors and functions for the lysophospholipid growth factos lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 1998, 12, 1589-98. 2. An, S., Goetzl, E.J., Lee, H. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. Cell Biochem. Suppl. 1998, 30-31, 147-57.