Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

ch-Alk2

  • Product Code: X1482P
  • Size: 250 µg
  • Price (USD): $249

Cat #

X1482P		 Quantity:      

Data Sheet

Product Name

ch- Alk2

Synonyms

Activin Receptor-Like Kinase 2

Host/Source

Sheep

Isotype

IgG

Product Type

Polyclonal Antibody

Reactivity

Chicken

Applications

Western Blot

Purification

Ammonium Sulfate Precipitation

Size

250 µg

Price (USD)

$249

Background

Activin Receptor-Like Kinase 2 is a member of the superfamily of type I receptors for transforming growth factor-? (TGF-?). This receptor binds both activin and bone morphogenic proteins (BMPs). In mice, these receptors are expressed mainly in the extraembryonic visceral endoderm before gastrulation and later in both embryonic and extraembryonic cells during gastrulation. Also, it has been shown that ALK2 associates with and phosphorylates Smad1 and also regulated Smad5 and Smad8 phosphorylation. Additionally, it induces the Tlx2 promoter in the absense of BMP7.

Immunogen

Recombinant protein derived from the extracellular domain of the chicken ALK2 protein. Protein shares significant homology with the mouse, rat and human sequences.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Product Image

Image Legend

Western blot using ALK-2 antibody (cat. no. X1482P) on ALK-2 fusion protein.

Database Links:

SwissProtQ90ZK6Chicken

References

1. Lai, Y.T., et al. 'Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation.' Dev. Biol. 2000, 222, 1-11. 2. Gu, Z., et al. 'The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo.' Development 1999, 126, 2551-2561. 3. Macias-Silva, M., et al. 'Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.' J. Biol. Chem. 1998, 273, 25628-25636