Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Adenovirus type 2 E1A

  • Product Code: X1317M
  • Size: 100 µg
  • Price (USD): $234

Cat #

X1317M		 Quantity:      

Product Name

Adenovirus type 2 E1A

Host/Source

Mouse

Clone

M73

Isotype

IgG2a

Product Type

Monoclonal Antibody

Purification

Protein A/G Chromatography

Size

100 µg

Price (USD)

$234

Background

Human cells-1 has a high level of expression of Adenovirus Type 5 EIA. The early region (EIA) of the adenovirus genome plays a central role in cellular transformation and regulation of gene expression. The adenovirus early gene product EIA is a potent stimulator of cellular proliferation, which when overexpresed can overcome the growth inhibitory effects of TGF-beta. The EIA region encodes a series of related proteins (35-46kDa) with multifunctional capabilities and form a specific complex with the retinoblastoma tumor suppressor gene product (Rb protein). The EIA and EIB regions together comprise the tranforming region of adenovirus. While expression of EIA alone is sufficient to immortalize primary cells, complete transformation requires the additional exrpession of the EIB region. Several conserved regions of EIA are similar to portions of other viral oncoproteins like the HPV-16 and SV40 large T antigen.

Immunogen

Adenovirus

Formulation

Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide. Also available without BSA and azide at 1mg/ml.

Customer Storage

Store vial below 0ºC.

References

1. Harlow E, et al. (1986)Mol Cell Biol, 6:1579-1589 2. Harlow E, et al. (1985) J Virol, 3:533-546. 3. Whyte P, et al. (1988) Nature, 334:124-129 4. Klein g, et al. (1987) Science 238:1539-1544