Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

IP-10

  • Product Code: X1250C
  • Size: 20 µg
  • Price (USD): $315

Cat #

X1250C		 Quantity:      

Product Name

IP-10

Synonyms

Interferon-? Inducible Protein-10; CXCL10

Product Type

Synthetic Protein

Applications

Activity Assay

Size

20 µg

Price (USD)

$315

Background

IP-10 was originally identified as an IFN-g-inducible gene in monocytes, fibroblasts and endothelial cells. It has since been shown that IP-10 mRNA is also induced by LPS, IL-1b, TNF-a, IL-12 and viruses. Additional cell types that have been shown to express IP-10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes and smooth muscle cells. IP-10 is also expressed in psoriatic and lepromatous lesions of skin. The mouse homologue of human IP-10, Crg-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human IP-10. Human IP-10 cDNA encodes a 98 amino acid (aa) residue precursor protein with a 21 aa residue signal peptide that is cleaved to form the 77 aa residue secreted protein. The amino acid sequence of IP-10 identified the protein as a member of the chemokine a family that lacks the ELR domain. IP-10 has been shown to be a chemoattractant for activated T-lymphocytes. Recently, IP-10 has been reported to be a potent inhibitor of angiogenesis and to display a potent thymus-dependent antitumor effect. A chemokine receptor specific for IP-10 and Mig has been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes.

Formulation

Lyophilized

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

References

1. Luster, A.D., et al. 'Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 1985, 315, 672-676 2. Dewald, B., et al. 'IP-10, a gamma-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties.' Immunol. Lett. 1992, 32, 81-84 3. Neville, L.F., et al. 'The immunobiology of interferon-gamma-inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily.' Cytokine Growth Factor Rev. 1997, 8, 207-219