Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

NCC4

  • Product Code: X1246C
  • Size: 20 µg
  • Price (USD): $450

Cat #

X1246C		 Quantity:      

Product Name

NCC4

Synonyms

HCC-4; Liver-Expressed Chemokine (LEC); Lymphocyte and Monocyte Chemoattractant (LMC)

Product Type

Synthetic Protein

Applications

Activity Assay

Size

20 µg

Price (USD)

$450

Background

NCC-4 (also known as HCC-4) is a CC chemokine. It is a 97 amino acid protein. It exhibits less than 30% sequence identity to other CC chemokines. NCC-4 chemoattracts human monocytes and THP-1 cells. However it does not chemoattract resting lymphocytes or neutrophils. It has been found to supress proliferation of myeloid progenitor cells and induces calcium flux in THP-1 cells. This calcium flux can be desensitized by exposure to RANTES which suggests that NCC-4 and RANTES share the same receptor in THP-1 cells.

Formulation

Lyophilized

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

References

1. Shoudai, K. et al., 'Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC' Biochim. Biophys. Acta 1998: 1396, 273-277 2. Hedrick, J., et al., 'Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10.' Blood 1998: 91, 4242-4247 3. Youn, B.-S., et al., 'Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity.' Biochem. Biophys. Res. Commun. 1998: 247, 217-222