Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Interleukin-8

  • Product Code: X1240C
  • Size: 20 µg
  • Price (USD): $375

Cat #

X1240C		 Quantity:      

Product Name

Interleukin-8

Synonyms

Monocyte-Derived Neurophil Chemotactic Factor

Product Type

Synthetic Protein

Applications

Activity Assay

Size

20 µg

Price (USD)

$375

Background

Interleukin 8 (IL-8), formerly called monocyte-derived neutrophil chemotactic factor, belongs to the C-X-C chemokine family. It was originally discovered and purified independently by a number of laboratories as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil activating protein, neutrophil chemotactic factor, leukocyte adhesion inhibitor, granulocyte chemotactic protein and T-lymphocyte chemotactic factor. IL-8 consists of 72 amino acids with a molecular weight of 8 kDa. IL-8 exhibits chemotactic activity in vitro for T cells, basophils and neutrophils. IL-8 activates neutrophils to release lysosomal enzymes including myeloperoxidase, ?-mannosidase and ?-glucuronidase. IL-1, TNF, Lipopolysaccharides and viruses induce the production of IL-8 from fibroblasts, keratinocytes, endothelial cells, hepatoma cells, astrocytoma cells, glioblastoma cells, lung epithelial cells, synovial membrane cells, melanocytes, melanoma cells and gastric cancer cells.

Formulation

Lyophilized

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Database Links:

SwissProtP10145Human

References

1. Matsushima, K., et al. 'Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.' J. Exp. Med. 1988: 167, 1883-1893 2. Schroder, J.M., et al. 'Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity.' J. Immunol. 1987: 139, 3474-3483