Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

bax

  • Product Code: A100M
  • Size: 100 µg
  • Price (USD): $244

Cat #

A100M		 Quantity:      

Data Sheet

Product Name

bax

Synonyms

hbax, mouse anti human bax

Host/Source

Mouse

Clone

2D2

Isotype

IgG1

Product Type

Monoclonal Antibody

Reactivity

Human

Applications

Western Blot

Purification

Protein A/G Chromatography

Size

100 µg

Price (USD)

$244

Background

The immunogen for the anti-h bax was a synthetic peptide corresponding to amino acids 3 to 16 of the human bax sequence. Bax expression is associated with cell death regulation. The ratio of bax to other bcl-2 family members is believed to regulate apoptosis.

Immunogen

A synthetic peptide corresponding to amino acids 3 to 16 of the human bax sequence

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

21.2 - Bax-alpha 24.2 - Bax-beta

Database Links:

SwissProtQ07814Human (bax-beta)
SwissProtQ07812Human (bax-alpha)

References

1. Y.T. Hsu et. al. (1997) J. Biol. Chem., 272(21): 13829-13834

2. Y. T. Hsu et. al (1997) Proc. Natl. Acad. Sci. USA, 94: 3668-3672

3. Annis, M., et al, 'Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis' EMBO Journal 2005, 24, , 2096-2103

4. Soucie, E.L., et al, 'Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria' Molecular and Cell Biology 2001, 21, , 4725-4736


Product Specific References


This product has been used in:

1. Annis, M., et al, 'Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis' EMBO Journal 2005, 24, , 2096-2103
2. Soucie, E.L., et al, 'Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria' Molecular and Cell Biology 2001, 21, , 4725-4736
3. Karch, J., et al. ‘Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice.’ eLife, 2, e00772 (2013)