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Rabbit anti Human Zinc Finger Protein GLI1


Catalogue number: X2363P

Synonyms
Glioma-associated oncogene; Oncogene GLI

Product Type Antigen Immunoaffinity Purified Polyclonal
Units100 µg
HostRabbit
Species reactivity Human
Application Western Blot
Product Form
Affinity Purified

Background
Zinc Finger Protein GLI1 is a member of the Kruppel family of zinc finger proteins. It is thought that it may regulate the transcription of specific genes during normal development and may play a role in craniofacial development and digital development. It also may be involved in the development of the central nervous system and gastrointestinal tract. This protein mediates SHH signaling and thus cell proliferation and differentiation. It has been localized to the cytoplasm and nucleus. It is tethered in the cytoplasm by binding to SUFU and activation and translocalization to the nucleus is promoted by interation with STK36. Protein expression is amplified in glioblastoma cells. Defects in the GLI1 protein may be a cause of breast cancer.

Positive Control
Protein found in testis, myometrium and fallopian tube.

Immunogen
Synthetic peptide derived from human zinc finger protein GLI1.

Purification Method
Antigen Immunoaffiinity Purification

Concentration
Lot specific, see vial

Formulation
Provided as solution in phosphate buffered saline with 0.08% sodium azide

Functional Analysis
Western Blotting

Applications
Antibody can be used for Western blotting (1:400 starting dilution). Optimal concentration should be evaluated by serial dilutions.

Storage
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Ship Conditions
Ship on gel ice, store at -20ºC immediately upon arrival

Product Stability
Products are stable for one year from purchase when stored properly

References
1. Kinzler, K.W., et al. 'The GLI gene is a member of the Kruppel family of zinc finger proteins.; Nature 332:371-374(1988). 2. Wang, Z.Q., et al. 'Identification of polymorphic variants of the GLI1 oncogene.; J. Invest. Dermatol. 115:328-329(2000).

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

Safety Datasheet(s) for this product:

Sodium Azide
/wp-content/uploads/2018/07/Antibody-SDS-with-Sodium-AzideV2.pdf

Rabbit anti Human Zinc Finger Protein GLI1

$249.00