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Sphingomyelin Phosphodiesterase 3

Catalogue number: X2287B

Product Type Blocking Peptide
Units50 µg
Species reactivity Human
Application Western Blot
Western Blotting

Sphingomyelin phosphodiesterase 3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these two cellular events independently. It also hydrolyzes sphingosylphosphocholine. Sphingomyelin phosphodiesterase 3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It likely acts as a regulator of postnatal development and participates in bone and dentin mineralization. It is activated by unsaturated fatty acids and phosphatidylserine. it is predominantly expressed in the brain.

Synonyms: nSMase2; Neutral sphingomyelinase 2; EC


Product Form: Unconjugated

Formulation: Provided as solution in phosphate buffered saline

Concentration: See vial for concentration

For use with Sphingomyelin Phosphodiesterase 3 polyclonal antibodies (Cat. No. X2359P & X2360P).

Functional Analysis: Western Blotting

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Product Stability: Products are stable for one year from purchase when stored properly

Shipping Conditions: Ship at ambient temperature, freeze upon arrival

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.

Protein Reference(s)

Database Name: UniProt

Accession number: Q9NY59

Sphingomyelin Phosphodiesterase 3