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SMase Activation Associated Factor

Catalogue number: X2289B

Product Type Blocking Peptide
Units50 µg
Species reactivity Human
Application Western Blot
Western Blotting

Novel adaptor protein which mediates the activation of sphingomyelinase by receptors such as tumor necrosis factor receptor type 1 and CD40 and subsequent apoptosis in cardiomyocytes. Inhibition of this factor may provide a novel intervention point for reducing ischemia/reperfusion injury.

Synonyms: nSMAF; Neutral sphingomyelinase (N-SMase) activation associated factor


Immunogen: Synthetic peptide derived from human NSMAF protein.


Product Form: Unconjugated

Formulation: Provided as solution in phosphate buffered saline

Concentration: See vial for concentration

For use with FXBW7 polyclonal antibodies (Cat. No. X2314P & X2336P).

Functional Analysis: Western Blotting

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Product Stability: Products are stable for one year from purchase when stored properly

Shipping Conditions: Ship at ambient temperature, freeze upon arrival

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.

1. O’Brien, N.W., et al. 'Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death.' Circ Res. 2003 Apr 4;92(6):589-91. 2. Segui, B., et al. 'CD40 Signals apoptosis through FAN-regulated activation of the sphinogmyelin-ceramide pathway.' J Biol Chem. 1999; 274: 37251–37258 3. Adam-Klages, S., et al. 'FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase.' Cell. 1996; 86: 937–947. 4. Segui, B., et al. 'Involvement of FAN in TNF-induced apoptosis.' J Clin Invest. 2001; 108: 143–151.

Protein Reference(s)

Database Name: UniProt

Accession number: Q8IW26

Species Accession: Human

SMase Activation Associated Factor