SMase Activation Associated FactorCatalogue number: X2289B
|Product Type||Blocking Peptide|
Novel adaptor protein which mediates the activation of sphingomyelinase by receptors such as tumor necrosis factor receptor type 1 and CD40 and subsequent apoptosis in cardiomyocytes. Inhibition of this factor may provide a novel intervention point for reducing ischemia/reperfusion injury.
Synonyms: nSMAF; Neutral sphingomyelinase (N-SMase) activation associated factor
Immunogen: Synthetic peptide derived from human NSMAF protein.
Product Form: Unconjugated
Formulation: Provided as solution in phosphate buffered saline
Concentration: See vial for concentration
For use with FXBW7 polyclonal antibodies (Cat. No. X2314P & X2336P).
Functional Analysis: Western Blotting
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: Products are stable for one year from purchase when stored properly
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
1. O’Brien, N.W., et al. 'Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death.' Circ Res. 2003 Apr 4;92(6):589-91. 2. Segui, B., et al. 'CD40 Signals apoptosis through FAN-regulated activation of the sphinogmyelin-ceramide pathway.' J Biol Chem. 1999; 274: 37251–37258 3. Adam-Klages, S., et al. 'FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase.' Cell. 1996; 86: 937–947. 4. Segui, B., et al. 'Involvement of FAN in TNF-induced apoptosis.' J Clin Invest. 2001; 108: 143–151.
Database Name: UniProt
Accession number: Q8IW26
Species Accession: Human
SMase Activation Associated Factor