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S100P-Binding Protein

Catalogue number: X2772B

Product Type Blocking Peptide
Units50 µg
Application Blocking Peptide

Background
This peptide is the immunogen used to make Cat # X2757P. The function of this binding protein is not fully known. It is known to interact with the S100P and colocalizes with S100P in the nucleus. S100P may stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In pancreas, expressed predominantly in islet cells and to a lesser extent in acinar cells, but not expressed in ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Detected in pancreatic ductal adenocarcinoma cells (at protein level). Not detected in non-neoplastic ductal epithelium (at protein level). Blocking Peptide to Cat # X2757P.

Synonyms: S100PBP

Product

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

Concentration: See vial for concentration

Applications
Optimal concentration should be evaluated by serial dilutions.

Functional Analysis: Neutralizing

Storage
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Product Stability: Products are stable for one year from purchase when stored properly

Shipping Conditions: Ship at ambient temperature, freeze upon arrival

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.


Safety Datasheet(s) for this product:
EA_Sodium Azide
/wp-content/uploads/SDS/Antibody SDS with Sodium AzideV2.pdf

S100P-Binding Protein

$125.00


Figure01 – Legend: CHO cells were trasfected with pSR-α huEphB1/HA, driving expression of HA epitope tagged EphB1. Cell lysates (200-300µg protein) were immunoprecipitated using 5 µl rabbit-anti-sheep antibody. Immunocomplexes were recovered on Protein A/G-Sepharose, separated by SDS-PAGE and EphB1/HA protein was detected by immunoblot using an anti-HA epitope antibody (Cat. No. X1000), and an anti-mouse IgG/peroxidase conjugate. Sheep were immunized with the following GST fusion proteins from EphB1 (huELK) sequences: Cy: aa 566-984 SAM: aa 883-984 EXT: aa 16-351