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Roundabout homolog 1, ROBO1


Catalogue number: X2335B

Synonyms
H-Robo-1, Deleted in U twenty twenty

Product Type Blocking Peptide
Units50 µg
HostRabbit
Species reactivity Human
Application Western Blot
Product Form
Unconjugated

Background
Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line.

Positive Control
Widely expressed, with exception of kidney.

Immunogen
Synthetic peptide derived from human ROBO1 protein

Concentration
See vial for concentration

Formulation
Provided as solution in phosphate buffered saline

Functional Analysis
Western Blotting

Applications
For use with ROBO1 polyclonal antibodies (Cat. No. X2313P and X2334P).

Storage
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Ship Conditions
Ship at ambient temperature, freeze upon arrival

Product Stability
Products are stable for one year from purchase when stored properly

References
1. Brose K., Bland K.S., Wang K.H., Arnott D., Henzel W., Goodman C.S., Tessier-Lavigne M., Kidd T.; Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.; Cell 96:795-806(1999). 2. Dallol A., Forgacs E., Martinez A., Sekido Y., Walker R., Kishida T., Rabbitts P., Maher E.R., Minna J.D., Latif F.; Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers.; Oncogene 21:3020-3028(2002).

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

Safety Datasheet(s) for this product:

Roundabout homolog 1, ROBO1

$119.00

SKU: X2335B Categories: ,