Exalpha Biologicals, Inc.

NEW ARTICLES IN LIPID SIGNALING

Valentine, W.J., et al. "Subtype-specific residues involved in ligand activation of the EDG-family lysophosphatidic acid receptors." J. Biol. Chem. 2008 Mar 3; [Epub ahead of print] (Click here for abstract)

Jo, S.K., et al. "Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease." Kindey Int. 2008 Mar 5; [Epub ahead of printe] (Click here for abstract)

Huwiler, A., et al. "New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets." Biochem. Pharmacol. 2008 Jan 5; [Epub ahead of print] (Click here for abstract)

Ptasynska, M.M., et al. "Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells." Mol. Cancer Res. 2008, 6(3):352-363. (Click here for abstract)

LOOKING AT PI3 KINASE SIGNALING PATHWAY……

Miled, N., et al. (2007). Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317:239-242 (Click here for abstract)

Lee, J.Y., et al. (2007). PI3K charges ahead. Science 317:206-207 (Click here for abstract)

Look to Exalpha’s family of products

P110 Mouse Monoclonal Antibody Clone 2G2, Cat #A115M
PTEN Sheep Polyclonal Antibody, Cat #D100P

Zhao, Y., et al. "Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells." Biochem J. 2005, 385:493-502. (click here for abstract)


Search:	Assay Kits • ApoMark™ DNA Fragmentation Apoptosis Detection Kit • Phospho-ERK1/2 ELISA Kit • Human TNFalpha ELISA Kit Lipid Signaling Family of Products Including antibodies to: • Lass1, Lass2, Lass3, Lass4 & 6 (LAG1 Longevity Assurance Homologs) • Neutral Sphingomyelin Phosphodiesterase 3 (nSMase2, Neutral Sphingomyelinase 2) • Neutral Sphingomyelinase Activation Associated Factor (nSMAF) • Ceramide Kinase • Sphingosine Kinase 1 & 2, as well as Sphingosine Kinase 2, Long Form • S1P and LPA Receptors • LPP1, LPP2, LPP3, LPP4 Also, Active Recombinant Enzymes: • Sphingosine Kinase 1 and Sphingosine Kinase 2 • Sphingosine Kinase 2, Long Form • Sphingosine Kinase 1a, Mouse BrdU Proliferation Assays/Kits • BrdU Colorimetric ELISA • BrdU Chemiluminescent ELISA • BrdU IHC Kit Flow Cytometry/CD antibodies • CD 56 - the superior CD56 available today. Neurobiology Product Lines Including antibodies to: • 3-Nitrotyrosine (Cat. No. X1719M) (pdf) - Antibody raised to the nitrotyrosine molecule only, not peroxynitrite-treated proteins. Does not cross-react with S-nitrosothiols. • NGF (neutralizes) • Calcium Channels • Potassium Channels Wnt Pathway Antibodies including…. • LEF (Cat # X1076M binds all LEF isoforms) • TCF3, 4 • Beta Catenein	NEW ARTICLES IN LIPID SIGNALING Valentine, W.J., et al. "Subtype-specific residues involved in ligand activation of the EDG-family lysophosphatidic acid receptors." J. Biol. Chem. 2008 Mar 3; [Epub ahead of print] (Click here for abstract) Jo, S.K., et al. "Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease." Kindey Int. 2008 Mar 5; [Epub ahead of printe] (Click here for abstract) Huwiler, A., et al. "New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets." Biochem. Pharmacol. 2008 Jan 5; [Epub ahead of print] (Click here for abstract) Ptasynska, M.M., et al. "Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells." Mol. Cancer Res. 2008, 6(3):352-363. (Click here for abstract) LOOKING AT PI3 KINASE SIGNALING PATHWAY…… Miled, N., et al. (2007). Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317:239-242 (Click here for abstract) Lee, J.Y., et al. (2007). PI3K charges ahead. Science 317:206-207 (Click here for abstract) Look to Exalpha’s family of products P110 Mouse Monoclonal Antibody Clone 2G2, Cat #A115M PTEN Sheep Polyclonal Antibody, Cat #D100P Zhao, Y., et al. "Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells." Biochem J. 2005, 385:493-502. (click here for abstract) (Submit a publishsed paper or poster referencing Exalpha products and we will send you a $100 credit toward your next Exalpha purchase.)