Sheep anti Chicken Alk2Catalog number: X1482P
Activin Receptor-Like Kinase 2 is a member of the superfamily of type I receptors for transforming growth factor- (TGF- ). This receptor binds both activin and bone morphogenic proteins (BMPs). In mice, these receptors are expressed mainly in the extraembryonic visceral endoderm before gastrulation and later in both embryonic and extraembryonic cells during gastrulation. Also, it has been shown that ALK2 associates with and phosphorylates Smad1 and also regulated Smad5 and Smad8 phosphorylation. Additionally, it induces the Tlx2 promoter in the absense of BMP7.
Synonyms: Activin Receptor-Like Kinase 2
Immunogen: Recombinant protein derived from the extracellular domain of the chicken ALK2 protein. Protein shares significant homology with the mouse, rat and human sequences.
Product Form: Unconjugated
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
Purification Method: Ammonium Sulfate Precipitation
Concentration: See vial for concentration
Antibody can be used for Western blotting (5-10 µg/ml), immunoprecipitation (5 µg/mg of protein lysate and immunohistochemistry on paraffin embedded tissue sections (5-10 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Functional Analysis: Western Blotting
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: See expiration date on vial
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.
1. Lai, Y.T., et al. 'Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation.' Dev. Biol. 2000, 222, 1-11. 2. Gu, Z., et al. 'The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo.' Development 1999, 126, 2551-2561. 3. Macias-Silva, M., et al. 'Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.' J. Biol. Chem. 1998, 273, 25628-25636
Database Name: SwissProt
Accession Number: Q90ZK6
Species Accession: Chicken
Safety Datasheet(s) for this product:
Sheep anti Chicken Alk2
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" Western blot using ALK-2 antibody (cat. no. X1482P) on ALK-2 fusion protein."