Rabbit anti Human FLAPCatalog number: X2318P
Antigen Immunoaffinity Purified Polyclonal
Seems to be required for the activation of 5-LO (5-lipoxygenase). Could play an essential role in the transfer of arachidonic acid to 5-LO. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Genetic variations in FLAP may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Synonyms: FLAP; Arachidonate 5-lipoxygenase-activating protein; MK 886 binding protein
Immunogen: Synthetic peptide derived from human FLAP protein.
Product Form: Affinity Purified
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
Purification Method: Antigen Immunoaffiinity Purification
Concentration: Lot specific, see vial
Antibody can be used for Western blotting (1:400 starting dilution). Optimal concentration should be evaluated by serial dilutions.
Functional Analysis: Western Blotting
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: See expiration date on vial
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.
1. Dixon, R.A.F., et al. 'Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis.; Nature 343:282-284(1990). 2. Helgadottir, A., et al. 'The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.; Nat. Genet. 36:233-239(2004).
Database Name: UniProt
Accession Number: P20292
Species Accession: Human
Safety Datasheet(s) for this product:
Rabbit anti Human FLAP
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" Western blot using antigen immunoaffinity purified and FLAP antibody (Cat. No. X2318P) on human kidney cell lysate. Lysate used at 15 µg/lane. Antibody used at 5 µg/ml. Secondary antibody, mouse anti-rabbit HRP (Cat. No. X1207M), used at 1:75k dilution. Visualized using Pierce West Femto substrate system. Exposure for 5 minutes "