Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Anti human interleukin 1 receptor antagonist (hIL-1ra)

  • Product Code: l139M
  • Size: 500 µg
  • Price (USD): $299

Cat #

l139M		 Quantity:      

Product Name

Anti human interleukin 1 receptor antagonist (hIL-1ra)

Synonyms

IL-1RN, hIL-1ra, ICIL-1RA, IL1 inhibitor, IL1F3

Host/Source

Mouse

Clone

AS17

Isotype

IgG1

Product Type

Monoclonal Antibody

Reactivity

Human

Applications

ELISA

Purification

Protein A/G Chromatography

Size

500 µg

Price (USD)

$299

Background

Interleukin 1 Receptor Antagonist inhibits the activity of IL-1 by binding to its receptor and has no IL-1 like activity. Genetic variation in IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA), also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis (bone inflammation in multiple places), periostitis (inflammation of the membrane surrounding the bones), and pustulosis (due to skin inflammation) from birth.

Immunogen

Hybridoma derived from the fusion of splenocytes from BALB/c mice immunized with human recombinant interleukin 1 receptor antagonist and mouse myeloma cells.

Positive Control

Recognizes human IL-1RA. Does not recognize hIL-1a, hIL-1b or a panel of other human cytokines.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

20.055

Database Links:

SwissProtP18510Human

References

1. Chen, Z., et al. 'Effects of interleukin-1alpha, interleukin-1 receptor antagonist, and neutralizing antibody on proinflammatory cytokine expression by human squamous cell carcinoma lines.' Cancer Res. 1998, 58, 3668-3676 2. Towbin, H., et al. 'Monoclonal antibody based enzyme-linked and chemiluminescent assays for the human interleukin-1 receptor antagonist. Application to measure hIL-1ra levels in monocyte cultures and synovial fluids.' J. Immunol. Methods 1994, 170, 125-135