Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc.

EDG3 (S1P3) (N Terminal) DISCONTINUED

  • Product Code: c175m
  • Size: 100 µg
  • Price (USD): $425

Cat #

c175m		 Quantity:      

Product Name

EDG3 (S1P3) (N Terminal) DISCONTINUED

Synonyms

Endothelial Cell Differentiation Gene-3 Receptor N-Terminal

Host/Source

Mouse

Clone

AS60

Isotype

IgG

Product Type

Monoclonal Antibody

Reactivity

Human, Rat

Applications

Western Blot

Size

100 µg

Price (USD)

$425

Background

EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing and other tissues.

Immunogen

Human Endothelial Differentiation Gene -3 unique N-terminal peptide.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

42.3

Database Links:

SwissProtQ99500Human

References

1. Goetzl EJ and An, S. Diversity of cellular receptors and functions for the lysophospholipid growth factos lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 1998, 12, 1589-98. 2. An, S., Goetzl, E.J., Lee, H. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. Cell Biochem. Suppl. 1998, 30-31, 147-57.