Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

EDG2, C terminal

  • Product Code: c174ps
  • Size: 50 µg
  • Price (USD): $229

Cat #

c174ps		 Quantity:      

Product Name

EDG2, C terminal

Synonyms

EDG-2 Ct, Rabbit anti human endothelial cell differentiation gene 2, c terminal

Host/Source

Rabbit

Isotype

IgG

Product Type

Polyclonal Antibody

Reactivity

Human

Applications

Western Blot

Purification

Ammonium Sulfate Precipitation

Size

50 µg

Price (USD)

$229

Background

Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca 2+ ]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.

Immunogen

KLH conjugated synthetic peptide corresponding to the a.a. 328-344 of human EDG 2.

Positive Control

Specificity: Recognizes an epitope on human EDG 2 between a.a. 328-344

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

References

1. Fukushima, N., et al., Proc. Natl.Acad. Sci. 95: 6151,1998. 2. Goetzl, E., et al.,J. of Immun.162:2049, 1992.