Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc. is now a US distributor for Nordic-Mubio products

Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and our focus is on developing antibodies targetting Cell Adhesion, Nuclear and Cytoskeletal Proteins.

Nordic-MUbio is one of the leading antibody companies developing antibodies for zebrafish research – we currently have over 50 antibodies validated for immunofluorescence in zebrafish.

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Akazawa, Y., et al. "Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis" PLoS ONE 8(12): e82322

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Homa, N.J., et al. "Epstein-Barr Virus Induces Global Changes in Cellular mRNA Isoform Usage That Are Important for the Maintenance of Latency" J. Virol., 2013, 87, 12291-12301

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Exalpha Biologicals, Inc.

Lysophosphatidic Acid Receptor 1 CT (EDG-2)

  • Product Code: c174p
  • Size: 100 µg
  • Availability: In Stock In Stock
  • Price (USD): $438

Cat #

c174p		 Quantity:      

Product Name

Lysophosphatidic Acid Receptor 1 CT (EDG-2)

Synonyms

Endothelial Cell Differentiation Gene Receptor 2; Lysophosphatidic Acid Receptor 1

Host/Source

Rabbit

Isotype

IgG

Product Type

Polyclonal Antibody

Reactivity

Human

Applications

Western Blot

Purification

Ammonium Sulfate Precipitation

Size

100 µg

Price (USD)

$438

Background

Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.

Immunogen

Synthetic peptide derived from the C terminal of the EDG2 receptor.

Positive Control

RH7777 Cells Transfected with EDG2/LPA1protein

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

50

Database Links:

SwissProtQ92633Human

References

1. Fukushima, N., et al., 'A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc. Natl.Acad. Sci. USA 1998, 95, 6151-6156

2. Goetzl, E., et al., 'Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax.' J. Immunol. 1999, 162, 2049-2056

3. Zheng, Y., et al. 'Lysophosphatidic acid receptor-selection effects on Jurkat T cell migration through a matrigel model basement membrane.' J. Immunol. 2001, 166, 2317-2322

4. Parrill, A.L., et al. 'Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.' J. Biol. Chem. 2000, 275, 39379-39384.


Product Specific References


This product has been used in:

1. Hu, Xiaojie, et al, 'Lysophosphatidic acid (LPA) protects primary chronic lymphocytic leukemia (CLL) cells from apoptosis through LPA receptor activation of the anti-apoptotic protein AKT/PKB' Journal of Biological Chemistry 2005, 280, , 9498-9508
2. Shida, Dai, et al, 'Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer' Laboratory Investigation 2004, 84, , 1352-1362
3. Shida, Dai et al, 'Lysophosphatidic Acid (LPA) Enhances the Metastatic Potential of Human Colon Carcinoma DLD1 Cells through LPA1' Cancer Research 2003, 63, , 1706-1711