Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

VipR 2 (Vasoactive Intestinal Peptide Rec-2) (DISCONTINUED)

  • Product Code: Z140M
  • Size: 100 µg
  • Price (USD): $300

Cat #

Z140M		 Quantity:      

Product Name

VipR 2 (Vasoactive Intestinal Peptide Rec-2) (DISCONTINUED)

Host/Source

Mouse

Clone

AS69

Isotype

IgG1

Product Type

Monoclonal Antibody

Reactivity

Human, Rat

Applications

Western Blot, Immunohistochemistry

Purification

Protein A/G Chromatography

Size

100 µg

Price (USD)

$300

Background

There are 2 Vasoactive intestinal peptide receptors, VIPR1 and VIPR2. These receptors are G-protein-coupled receptors. VIP receptors is differentially expressed on T cells, macrophages, mast cells, platelets, and non-immune cells. VIP receptors are found in the CD3 positive zone around lymphoid follicles. In the spleen, VIP receptors are detected in periarterial lymphatic sheaths. In the thymus, VIP receptors are present in cortex and medulla. VIP receptors are expressed in tumor metastasis and on human colonic adenocarcinoma cell lines, HT29, SW403, DLD-1 and Caco-2. VIPR1 mediates suppression of chemotaxis and matrix metalloproteinase expression elicited by some cytokines and chemokines. Although structurally-related to a second receptor for VIP (VIPR2), there are differences in the expression and function of VIPR1 and VIPR2. VIPR1 on tumor cells mediates tumor cell migration induced by VIP. VIPR receptors are novel targets. They should be of interest to researchers in many fields since they are broadly related. Differential expression may be important in tumor cell diagnosis and regulation. These receptors are likely targets for drug discovery.

Immunogen

Mixture of clones produced by the fusion of splenocytes from mice immunized with synthetic peptide corresponding to amino acids 105-122 ot human VIPR2 receptor and mouse myeloma cells.

Positive Control

A431 cell lysate. Specificity: Recognizes the human VIPR2 immunizing peptide.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Product Image

Image Legend

Immunohistochemical staining of rat hippocampus stained with VIPR2 antibody (Cat. No. Z140M) at 5 µg/ml.

Database Links:

SwissProtP35000Rat
SwissProtP41587Human

References

1. Goetzl, E.J., et al. Specific recognition of the human neuroendocrine receptor for vasoactive intestinal peptide by anti-peptide antibodies. Mol. Cell. Neurosci. 1994, 5, 145-152 2. Lutz, E.M., et al. Structure of the human VIPR2 gene for vasoactive intestinal peptide receptor type 2. FEBS Lett. 1999, 458, 197-203


Product Specific References


This product has been used in:

1. Ventzislav, Petrov et al, 'Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension. Ventzislav, Petrov et al. ' The Journal of Clinical Investigation 2003, 111, 9, 1339-1346