Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc.

VipR 1 (Vasoactive Intestinal Peptide Rec-1)

  • Product Code: Z135M
  • Size: 100 µg
  • Price (USD): $300

Cat #

Z135M		 Quantity:      

Product Name

VipR 1 (Vasoactive Intestinal Peptide Rec-1)

Host/Source

Mouse

Clone

AS58

Isotype

IgG2a

Product Type

Monoclonal Antibody

Reactivity

Human, Rat

Applications

Western Blot, Flow Cytometry

Purification

Protein A/G Chromatography

Size

100 µg

Price (USD)

$300

Background

Function: Human Vasoactive Intestinal Peptide Receptor-1 (VIPR1) is a G-protein-coupled receptor for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP). VIPR1 mediates suppression of chemotaxis and matrix metalloproteinase expression elicited by some cytokines and chemokines. Although structurally-related to a second receptor for VIP (VIPR2), there are differences in the expression and function of VIPR1 and VIPR2. VIPR1 on tumor cells mediates tumor cell migration induced by VIP. Cell Distribution: hVIPR1 is expressed on T cells, macrophages, mast cells, platelets, and non-immune cells. VIP receptors are found in the CD3 positive zone around lymphoid follicles. In the spleen, VIP receptors are detected in periarterial lymphatic sheaths. In the thymus, VIP receptors are present in cortex and medulla. VIP receptors are expressed in tumor metastasis and on human colonic adenocarcinoma cell lines, HT29, SW403, DLD-1 and Caco-2.

Immunogen

Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with full length, recombinant VIPR1 receptor protein and mouse myeloma cells.

Positive Control

A431 and HUT78 cell lysate Specification: Recognizes human VIPR1. Does not recognize cells expressing only VIPR2.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

52

Product Image

Image Legend

Western blot analysis using anti-VIPR1 antibody on A431 cell lysate at 1 µg/ml (1) and 10 µg/ml (2).

Database Links:

SwissProtP30083Rat
SwissProtP32241Human

References

1. Goetzl, E.J., et al. Specific recognition of the human neuroendocrine receptor for vasoactive intestinal peptide by anti-peptide antibodies. Mol. Cell. Neurosci. 1994, 5, 145-152 2. Pei, L. 'Molecular cloning of a novel transcriptional repressor protein of the rat type 1 vasoactive intestinal peptide receptor gene.' J. Biol. Chem. 1998, 273, 19902-19908 3. Lara-Marquez, M., et al. 'Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T-cells.' J. Immunol. 2001, 166, 2522-2530


Product Specific References


This product has been used in:

1. Ventzislav, Petrov et al, 'Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension.' The Journal of Clinical Investigation 2003, 111, 9, 1339-1346