Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc.

BCRP (ATP-binding cassette sub-family G member 2)

  • Product Code: X2731P
  • Size: 100 µg
  • Price (USD): $355

Cat #

X2731P		 Quantity:      

Data Sheet

Product Name

BCRP (ATP-binding cassette sub-family G member 2)

Synonyms

Breast cancer resistance protein; CDw338; Mitoxantrane resistance-associated protein; Placenta-specific ATP-binding cassette transporter

Host/Source

Rabbit

Isotype

Ig

Product Type

Antigen Immunoaffinity Purified Polyclonal

Reactivity

Human

Applications

Immunohistochemistry (paraffin-embedded)

Purification

Antigen Immunoaffinity Purification

Size

100 µg

Price (USD)

$355

Background

BCRP acts as a xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

Immunogen

Synthetic peptide derived from human BCRP protein

Positive Control

Highly expressed in placenta

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

72kDa

Product Image

Image Legend

Immunohistochemical staining of normal human testis tissue using BCRP antibody (Cat. No. X2731P) at 10 µg/ml and detected using anti-Rabbit HRP secondary antibody and visualized using DAB substrate and hematoxylin counterstain.

Database Links:

SwissProtQ9UNQ0Human

References

1. Zhou, W., et al. 'The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype.' Nat. Med. 2001, 7, 1028-1034. 2. Itoda, M., et al. ''Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.' Drug Metab. Pharmacokinet. 2003, 18, 212-217. 3. Zamber, C.P., et al. 'Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.' Pharmacogenetics 2003, 13, 19-28.