Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Corticotropin-releasing hormone receptor 2

  • Product Code: X2726P
  • Size: 100 µg
  • Price (USD): $355

Cat #

X2726P		 Quantity:      

Data Sheet

Product Name

Corticotropin-releasing hormone receptor 2

Synonyms

CRF-R2; CRF2

Host/Source

Rabbit

Product Type

Antigen Immunoaffinity Purified Polyclonal

Reactivity

Human

Applications

Western Blotting, ELISA, Immunohistochemistry

Purification

Antigen Immunoaffiinity Purification

Size

100 µg

Price (USD)

$355

Background

CRF2 is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Expression levels shown to be comparable in adipose tissues and the heart of humans. Expression in adipose tissues suggests a functional role for CRH in human fat.

Immunogen

Synthetic peptide derived from the N-terminal region of the CRF2R protein.

Positive Control

Human colorectal tissue

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

48 kDa

Product Image

Image Legend

Staining of normal human colorectal tissue with CRFR1 antibody (Cat. No. X2726P) at 2 µg/ml.

Database Links:

SwissProtQ13324Human

References

1. Liaw, C.W., et al. 'Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid.' Endocrinology 1996, 137, 72-77.

2. Isfort, R.J., et al. 'Discovery of corticotropin releasing factor 2 receptor selective sauvagine analogues for treatment of skeletal muscle atrophy.' J. Med. Chem. 2005, 48, 262-265.

3. Argiles, J.M., et al. 'Effects of CRF2R agonist on tumor growth and cachexia in mice implanted with Lewis lung carcinoma cells.' Muscle Nerve 2008, 37, 190-195.

4. Tao, J., et al. 'Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway.' Cell Signal 2009, 21, 1436-1443.

5. Seres, J., et al. 'Corticotropin-releasing hormone system in human adipose tissue.' J. Clin. Endocrin. & Metab. 2004, 89, 965-970.