Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc.

Calcium Homeostasis Modulator Protein 1

  • Product Code: X2723P
  • Size: 100 µg
  • Price (USD): $355

Cat #

X2723P		 Quantity:      

Data Sheet

Product Name

Calcium Homeostasis Modulator Protein 1

Synonyms

CALHM1; FAM26C

Host/Source

Rabbit

Isotype

IgG

Product Type

Antigen Immunoaffinity Purified Polyclonal

Reactivity

Human

Applications

Western Blotting, ELISA

Purification

Ammonium Sulfate Precipitation

Size

100 µg

Price (USD)

$355

Background

CALHM1 controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration. It controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner. However, no association between CALHM1 and Alzheimer’s risk is unclear. Member of the FAM26 family of proteins. CALHM1 is predominantly expressed in the adult brain. It has also been detected in retinoic acid-differentiated SH-SY5Y cells. Also colocalizes with HSPA5 at the endoplasmic reticulum.

Immunogen

Synthetic peptide derived from human CALHM1 protein.

Positive Control

Human hepatocellular carcinoma

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Image

Image Legend

Staining on paraffin embedded human hepatocellular carcinoma sections. Primary Ab (immunoaffinity purified) at 10 µg/ml. Antigen retrieval used: 10 mM Na Citrate pH 6.0, 10 minutes pressure cooker method, developed with anti rabbit HRP and DAP substrate. Counterstained with methyl blue.

Database Links:

SwissProtQ8IU99Human

References

1. Dreses-Werringloer, U., et la. A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Ab Levels, and Alzheimer’s Disease Risk. Cell 2008, 133, 1149-1161

2. Bertram, L., et al. 'No association between CALHM1 and Alzheimer’s disease risk.' Cell 2008, 135(6), 993-994.

3. Cui, P.J., et al. 'CALHM1 P86L polymorphism is a risk for Alzheimer’s Disease in the Chinese population.' J. Alzheimers Dis. 2009, Epub ahead of