Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6)

  • Product Code: X2717B
  • Size: 50 µg
  • Price (USD): $113

Cat #

X2717B		 Quantity:      

Data Sheet

Product Name

Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6)

Product Type

Blocking Peptide

Reactivity

Blocking Peptide to Cat # X1593P

Applications

Blocking Peptide

Size

50 µg

Price (USD)

$113

Background

This peptide is the immunogen used to make Cat # X1593P. S1P4/EDG6 polyclonal antibody. EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine 1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs.

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Product Specific References


This product has been used in:

1. Ohotski, J., et al. ' Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.' British Journal of Cancer, Apr 2012, 106(8): 1453-1459.