Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

a1C Calcium Channel

  • Product Code: X2713P
  • Size: 100 µg
  • Price (USD): $355

Cat #

X2713P		 Quantity:      

Data Sheet

Product Name

a1C Calcium Channel

Synonyms

RBC-II; Cav1.2; Calcium channel ( L type) voltage gated 1c; Cacna1c

Host/Source

Rabbit

Isotype

IgG

Product Type

Antigen Immunoaffinity Purified Polyclonal

Reactivity

Human

Applications

Western Blot, Immunohistochemistry

Purification

Antigen Immunoaffiinity Purification

Size

100 µg

Price (USD)

$355

Background

Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1c gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). Calcium channels containing the alpha-1c subunit play an important role in excitation-contraction coupling in the heart.

Immunogen

Synthetic peptide derived from the rat alpha1C calcium channel conjugated to KLH

Positive Control

Normal human kidney tissue

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Product Image

Image Legend

Immunohistochemical staining of normal human kidney tissue with alpha1C calcium channel antibody (Cat. No. X2713P) at 15 µg/ml

Database Links:

SwissProtQ13936Human

References

1. Snutch,T.P et.al 'Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian' CNS Neuron 7 (1), 45-57 (1991) 2. Hansen, P.B. et.al 'Differential expression of T- and L-type voltage-dependent calcium channels in renal resistance vessels.' Circ Res;89(7):630-8 (2001) 3. Chung,Y.H. et.al 'Differential alterations in the distribution of voltage-gated calcium channels in aged rat cerebellum.' Brain Res 8;903(1-2):247-52.(2001)