Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc. is now a US distributor for Nordic-Mubio products

Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and our focus is on developing antibodies targetting Cell Adhesion, Nuclear and Cytoskeletal Proteins.

Nordic-MUbio is one of the leading antibody companies developing antibodies for zebrafish research – we currently have over 50 antibodies validated for immunofluorescence in zebrafish.

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Latest References

Akazawa, Y., et al. "Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis" PLoS ONE 8(12): e82322

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Homa, N.J., et al. "Epstein-Barr Virus Induces Global Changes in Cellular mRNA Isoform Usage That Are Important for the Maintenance of Latency" J. Virol., 2013, 87, 12291-12301

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Exalpha Biologicals, Inc.

beta-Actin (N-Terminal)

  • Product Code: X2672M
  • Size: 100 µg
  • Availability: In Stock In Stock
  • Price (USD): $180

Cat #

X2672M		 Quantity:      

Data Sheet

Product Name

beta- Actin (N-Terminal)

Host/Source

Mouse

Clone

BA3R

Isotype

IgG2b

Product Type

Monoclonal Antibody

Reactivity

Human, Mouse, Rat, Rabbit, Chicken

Applications

WB, ELISA, DOT BLOT,

Purification

Protein A/G Chromatography

Size

100 µg

Price (USD)

$180

Background

Actins are highly conserved proteins that are involved in cell motility, structure and integrity, processes that are crucial for tissue development and the development of organism. The actin cytoskeleton is one of the principal drivers of cell motility and is capable of responding to complex signaling cascades. Recent evidence suggests that it may play key roles in regulating apoptosis and aging. Beta actin is one of six different actin isoforms which have been identified. Like GAPDH, -actin is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.

Immunogen

-Actin N-terminal peptide-KLH conjugate

Positive Control

Recognizes native and denatured forms of -Actin (~42kDa)

Formulation

10mM PBS, pH 7.2, with 0.05% Sodium Azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Database Links:

SwissProtP29751Rabbit
SwissProtP60706Chicken
SwissProtP60711Rat
SwissProtP60710Mouse
SwissProtP60709Human

References

1. Ponte P., Ng S.Y., Engel J., Gunning P., Kedes L., Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA.
Nucleic Acids Res. 12:1687-1696(1984)

2. Nakajima-Iijima S., Hamada H., Reddy P., Kakunaga T.,Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.
Proc. Natl. Acad. Sci. U.S.A. 82:6133-6137(1985)

3. Procaccio V., Salazar G., Ono S., Styers M.L., Gearing M., Davila A., Jimenez R., Juncos J., Gutekunst C.-A., Meroni G., Fontanella B., Sontag E., Sontag J.-M., Faundez V., Wainer B.H. A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia. Am. J. Hum. Genet. 78:947-960(2006) [PubMed: 16685646] [Abstract]