A disintegrin and metalloproteinase domain-like protein decysin 1,ADAM-like protein decysin 1
Western Blot, ELISA
Ammonium Sulfate Precipitation
ADAMDEC1 is expressed in the immune system, by dendritic cells and macrophages. It may play an important role in the control of the immune response and during pregnancy.1 Due to the partial lack of a disintegrin domain and the total lack of a cysteine-rich domain, this protein has been placed in a novel subclass of the ADAM gene family2.
Synthetic peptide derived from the human ADAMDEC1 protein.
Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Staining on paraffin embedded normal human tonsil sections. Primary Ab (IgG cut or immunoaffinity purified) at 10 µg/ml. Antigen retrieval used: 10 mM Na Citrate pH 6.0, 10 minutes pressure cooker method., developed with anti rabbit HRP and DAP substrate. Counterstained with methyl blue.
1. UniProtKB/Swiss-Prot Acession # O152042. Bates, E.E. et. atl., The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprtease gene cluster on chromosome 8p12. Immunogenetics. 2002 May;54(2):96-105. Epub 2002 Mar 16,