Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

beta-Actin, cytoplasmic 1 (NT)

  • Product Code: X2408P
  • Size: 200 µg
  • Price (USD): $155

Cat #

X2408P		 Quantity:      

Data Sheet

Product Name

beta- Actin, cytoplasmic 1 (NT)

Host/Source

Rabbit

Isotype

Ig

Product Type

Polyclonal Antibody

Reactivity

Human

Applications

WB

Purification

Ammonium Sulfate Precipitation

Size

200 µg

Price (USD)

$155

Background

Actins are highly conserved proteins that are involved in cell motility, structure and integrity, processes that are crucial for tissue development and the development of organism. The actin cytoskeleton is one of the principal drivers of cell motility and is capable of responding to complex signaling cascades. Recent evidence suggests that it may play key roles in regulating apoptosis and aging. Beta actin is one of six different actin isoforms which have been identified. Like GAPDH, b-actin is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.

Immunogen

Synthetic peptide derived from the N-terminal of the beta-actin protein.

Positive Control

Human liver

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Image

Image Legend

Immunohistochemistry staining of normal human liver tissue using Actin antibody (Cat. No. X2408P) at 10 µg/ml.

Database Links:

SwissProtP60709Human

References

1. Ponte P., Ng S.Y., Engel J., Gunning P., Kedes L., Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA.
Nucleic Acids Res. 12:1687-1696(1984)

2. Nakajima-Iijima S., Hamada H., Reddy P., Kakunaga T.,Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.
Proc. Natl. Acad. Sci. U.S.A. 82:6133-6137(1985)

3. Procaccio V., Salazar G., Ono S., Styers M.L., Gearing M., Davila A., Jimenez R., Juncos J., Gutekunst C.-A., Meroni G., Fontanella B., Sontag E., Sontag J.-M., Faundez V., Wainer B.H. A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia. Am. J. Hum. Genet. 78:947-960(2006) [PubMed: 16685646] [Abstract]