The product of the DEGS1 gene is a member of the membrane fatty acid (sphingolipid delta 4) desaturase family. Reported to function by inserting double bonds at delta 4 position in fatty acids. DEGS1 is an intracellular enzyme. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. Two splice variants have been identified.
Synthetic peptide derived from the human DEGS1 protein
Placenta, normal human brain
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
1. Cadena, D.L., et al. 'The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis.; Biochemistry 36:6960-6967(1997).2. Ternes, P., et al. 'Identification and characterization of a sphingolipid delta 4-desaturase family.; J. Biol. Chem. 277:25512-25518(2002).