Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

SMO (Smoothened Homolog)

  • Product Code: X2377B
  • Size: 50 µg
  • Price (USD): $113

Cat #

X2377B		 Quantity:      

Data Sheet

Product Name

SMO (Smoothened Homolog)

Synonyms

Smoothened homolog [Precursor], SMO, Gx protein, SMO, SMOH

Host/Source

Rabbit

Isotype

IgG

Product Type

Blocking Peptide

Reactivity

Human

Applications

Western blot

Size

50 µg

Price (USD)

$113

Background

SMO is a G protein-coupled receptor (GPCR) that putatively associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. The binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). In basal cell carcinoma there are two somatic mutations SMO, D473-> H473 and R562 ->Q562.

Immunogen

peptide immunogen

Positive Control

Brain

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

86 kDa

Database Links:

SwissProtQ99835Human