Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery
Exalpha Biologicals, Inc.

Lass2

  • Product Code: X2307P
  • Size: 50 µg
  • Price (USD): $249

Cat #

X2307P		 Quantity:      

Data Sheet

Product Name

Lass2

Synonyms

LAG1 longevity assurance homolog 2, Tumor metastasis-suppressor gene 1 protein, SP260

Host/Source

Rabbit

Product Type

Antigen Immunoaffinity Purified Polyclonal

Reactivity

Human, Rat, Mouse

Applications

Western Blot

Purification

Antigen Immunoaffiinity Purification

Size

50 µg

Price (USD)

$249

Background

LASS2, a human homologue of the yeast longevity assurance gene LAG1 is highly expressed in liver and kidney as compared to the expression of the human LAG1 homologue LAG1Hs-1. LASS2 is located on chromosome 1q11. The LASS2 protein interacts with several membrane-associated receptors or transporters. LASS2 protein inhibits the colony formation of human hepatoma cells in vitro, which suggests that this gene may be involved in the regulation of cell growth.

Immunogen

Synthetic peptide derived from human Lass2 protein

Positive Control

liver and kidney

Formulation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Customer Storage

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Target Molecular Weight

44876

Product Image

Image Legend

Left: Immunohistochemical staining of normal human liver tissue using Lass2 antibody (Cat. No. X2307P) at 15 µg/ml. Right: Western blot analysis using LAG1 longevity assurance homolog 2 (Cat. # X2307P) at 10ug/ml on human placenta lysate (Cat. # X1635C) 14 ug/lane. Lane A] antibody alone, Lane B] conjugate alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:10K dilution (Cat. # X1207M). Exposure for 5 minutes

Database Links:

SwissProtQ3T1K1Rat
SwissProtQ924Z4Mouse
SwissProtQ96G23Human

References

1: Becker I, Wang-Eckhardt L, Yaghootfam A, Gieselmann V, Eckhardt M.Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2. Histochem Cell Biol. 2008 Feb;129(2):233-41. Epub 2007 Sep 28. 2: Wang X, Carré W, Saxton AM, Cogburn LA. Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken. Cytogenet Genome Res. 2007;117(1-4):174-88. 3:Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B. Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol Cancer Ther. 2007 Feb;6(2):712-22. 4: Yu Y, Lu H, Pan H, Ma JH, Ding ZJ, Li YY. Expression of LASS2 controlled by LAG1 or ADH1 promoters cannot functionally complement Lag1p. Microbiol Res. 2006;161(3):203-11. Epub 2005 Sep 22.