Exalpha Biologicals, Inc.

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Exalpha Biologicals, Inc.

5-HT7 Receptor (HTR7)

  • Product Code: X2140P
  • Size: 50 µg
  • Price (USD): $464

Cat #

X2140P		 Quantity:      

Data Sheet

Product Name

5-HT7 Receptor (HTR7)

Synonyms

5-HT-7, 5-HT7, 5HT7, HTR7

Host/Source

Rabbit

Isotype

IgG

Product Type

Antigen Immunoaffinity Purified Polyclonal

Reactivity

Human

Applications

Immunohistochemistry

Purification

Immunoaffinity Purification

Size

50 µg

Price (USD)

$464

Background

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Immunogen

3rd cytoplasmic domain of human

Positive Control

Human Brain

Formulation

Phosphate buffered saline containing 0.1% sodium azide

Customer Storage

Product should be stored at -70ºC. Aliquot to avoid freeze/thaw cycles

Product Image

Image Legend

HTR7 staining of formalin fixed paraffin embedded human brain (cortex) tissue at a dilution of 10 µg/ml. Antigen retrieval using a citrate buffer and steam/heat was utilized.

Database Links:

SwissProtP34969Human

References

1. Grueb, M., et al. 'Serotonin (5-HT7) Receptor-Stimulated Activation of cAMP-PKA Pathway in Bovine Corneal Epithelial and Endothelial Cells.' Ophthalmic. Res. 2012, 48, 22-27. 2. Tonini, M., et al. '5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum.' Gastroenterology 2005, 129, 1557-1566. 3. Russo, A., et al. '’In vitro’ postnatal expression of 5-HT7 receptors in the rat hypothalamus: an immunohistochemical analysis.' Brain Res. Dev. Brain Res. 2005, 154, 211-216. 4. Meuser, T., et al. '5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons.' Life Sci. 2002, 71, 2279-2289.